Table 1.

Determination of inflammatory and profibrotic markers in mice fed a STD, a HFD, or a HFD-Losartan at week 36

	STD	HFD	HFD-Losartan
Angiotensinogen	1.00 ± 0.14	0.94 ± 0.16	1.10 ± 0.19
Renin	1.00 ± 0.15	0.82 ± 0.10	0.92 ± 0.12
Type I collagen	1.00 ± 0.11	1.43 ± 0.18	0.97 ± 0.12
Type IV collagen	1.00 ± 0.09	1.42 ± 0.14*	1.04 ± 0.12
MCP-1	1.00 ± 0.18	4.16 ± 1.01*	2.73 ± 0.71

Values are means ± SE; n = 6–8 in each group.

HFD, high-fat diet; STD, standard diet; MCP-1, monocyte chemotattractant protein-1.

Quantitative real-time PCR was performed with kidney from all groups each normalized against β-actin. Statistical analyses were performed by one-way ANOVA followed by Newman-Keuls:

^*P ≤ 0.05 vs. mice on STD.