Fig. 7.

Cystometrogram traces of TβR-1 inhibition following intermediate (48 h) CYP-induced cystitis. A: representative pre-SB505124 baseline traces. B: representative post-SB505124 (5 μM) traces. Intravesical instillation of SB505124 (5 μM; B) significantly (P ≤ 0.001) decreased voiding frequency and increased bladder capacity (total infused 0.9% NaCl at the time micturition commenced; 2.5-fold), void volume (2.6-fold), and intercontraction intervals (2.5-fold) relative to pre-SB505124 baseline measurements (A). Representative traces (A and B) were from the same rat.