Fig. 1.
Visceromotor responses to colorectal distension (CRD). A: relative to C57BL/6 controls, transient receptor potential vanilloid 1 (TRPV1)-P2X3 double knockout (TPDKO) mice exhibited greater baseline responses to CRD (F1/144 = 5.8, *P < 0.05; Holms-Sidak post hoc tests, P < 0.01 at 45 and 60 mmHg CRD). B: intracolonic zymosan, but not saline, produced colorectal hypersensitivity in C57BL/6 mice (F1/24 = 6.4, P < 0.05), but not in TPDKO mice. C: visceromotor responses (not normalized) were used to generate stimulus-response curves in A; normalized responses were used for B and C. n = number of mice/group.