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. 2013 Aug 30;305(9):H1354–H1362. doi: 10.1152/ajpheart.00379.2013

Fig. 2.

Fig. 2.

Higher expression of pluripotency, cardiac lineage, and antiaging markers with longer telomeres in SJSCs. Compared with aged BMSCs, aged SJSCs showed higher expression of pluripotency markers such as octamer-binding transcription factor 4 (Oct-4), Nanog, sex-determining region Y box 2 (Sox-2), Kruppel-like factor 4 (Klf-4), and Rex-1 (A), cardiogenic differentiation markers such as Gata-4 and myocyte-specific enhancer factor 2C (Mef2c) (B), and antiaging markers such as sirtuin 1 (Sirt1) and telomerase reverse transcriptase (Tert) (C), as examined by RT-PCR. *P < 0.01 vs. BMSCs. D: aged SJSCs showed less senescence-associated β-galactosidase (β-gal) expression compared with aged BMSCs. E: confocal microscopy showed that aged SJSCs had a higher density of telomeres compared with aged BMSCs. F: Quantitative fluorescence in situ hybridization (FISH) analysis demonstrated that SJSCs maintain longer telomeres compared with BMSCs. Telomere shortening was delayed in aged SJSCs compared with aged BMSCs. *P < 0.05; #P < 0.001.