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A: effect of ventilation with a 10% O2-90% N2 gas mixture on pulmonary arterial pressure and the effect of intravenous injection of 10 mg/kg imatinib on the hypoxia-induced increase in pulmonary arterial pressure. B: effects of cyclooxygenase inhibition with sodium meclofenamate (5 mg/kg iv), phosphodiesterase type 4 inhibition with rolipram (1.5 mg/kg iv), and inhibition of ATP-sensitive K+ channels with glybenclamide (5 mg/kg iv). n, No. of experiments. *P < 0.05.
