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KCC4 activity is modulated by external pH (pH0). Xenopus laevis oocytes were injected with 10 ng KCC4 cRNA to assess the effect of pH0 on Cl−-dependent 86Rb+ uptake during hypotonic conditions. Preuptake and uptake solutions were pH titrated from 6.0 to 8.0. A negative correlation between KCC4-mediated 86Rb+ uptake and pH0 was found (R2 = 0.94, P < 0.05).
