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Acute acid load in rats. Zucker diabetic fatty (ZDF) rats and Con littermates were housed in metabolic cages. After a baseline urine collection, rats were given a single dose of NH4Cl (10 mmol/kg) by orogastric gavage, and urine was collected every 4 h. A: urinary pH (means ± SD). *P < 0.01 for Con vs. ZDF rats. B: AUC for urine NH4+/creatinine (median, IQR, and data range). *P < 0.001 for Con vs. ZDF rats.
