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Expression of transcription factors regulating antioxidant gene expression. Increasing age significantly decreased FOXO-4 and Nrf2 gene expression in aorta (A and B) and aortic valve (C and D), but these changes were relatively unaffected by MnSOD haploinsufficiency. Values are means ± SE; n = 4–14 mice/group. **Significant main effect of age with P value < 0.01; #individual group differences with P < 0.05.
