Fig. 5.

Expression of aging- and senescence-related genes in aorta. Sirtuin (Sirt) expression is largely unchanged with aging (A–G). Cyclin-dependent kinase inhibitor 2A (CDKN2A) expression, a marker of cellular senescence, was significantly increased by aging in aorta (H). MnSOD-haploinsufficiency did not significantly impact sirtuin or CDKN2A expression in the aorta from young or aged mice. Values are means ± SE; n = 4–14 mice/group. *Significant main effect of genotype with P < 0.01; **significant main effect of age with P value < 0.01; #individual group differences with P < 0.05.