Table 2.
Effects of aging and MnSOD-haploinsufficiency on vasomotor function in aorta
| Aorta |
||||
|---|---|---|---|---|
| Young |
Old |
|||
| WT | Het | WT | Het | |
| Relaxation | ||||
| Maximum relaxation to ACh, % | 62 ± 3 | 62 ± 1 | 49 ± 3** | 43 ± 3** |
| Concentration of ACh eliciting 50% of maximum relaxation to ACh | 7.5 ± 0.13 | 7.2 ± 0.1 | 7.0 ± 0.2 | 7.1 ± 0.1 |
| Maximum relaxation to sodium nitroprusside, % | 90 ± 2 | 91 ± 2 | 94 ± 2 | 96 ± 1** |
| Constriction | ||||
| Peak tension (PGF2α) | 1.2 ± 0.04 | 1.1 ± 0.06 | 1.78 ± 0.1** | 1.74 ± 0.1** |
| Peak tension (5HT) | 0.68 ± 0.07 | 0.68 ± 0.07 | 0.90 ± 0.04** | 0.86 ± 0.04** |
Values are means ± SE; n = 4–14 mice/group.
**
Significance versus young mice of same genotype.