Fig. 7.

Effect of depletion of circulating monocytes on CCR2-dependent host defense in mice with experimental Gram-negative pneumonia. A: comparison of blood neutrophil and monocyte concentration in mice treated with clodronate- or PBS-containing liposomes in mice on day 1 after intrapulmonary challenge with Klebsiella. Data represent means ± SE of representative data from 2 experiments; n = 3–5 for each group. B: lung viable bacterial content on day 3 after intrapulmonary challenge with Klebsiella in mice treated with clodronate- or PBS-containing liposomes. Each data point represents 1 animal, and horizontal lines indicate medians; pooled data from 3 experiments; *P < 0.05 (1-way ANOVA for A; Mann-Whitney for B).