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At 14 wk of age, rats received intracerebroventricular injection of saline or 10 μg leptin, and food intake was monitored at 4 h (A and C) and 22 h (B and D). Cumulative food intake (A and B) and suppression of food intake in response to leptin (C and D) were analyzed. *P < 0.05 vs. saline group; a,bGroups with different superscript letters differ from each other at P < 0.05 level.
