Table 3.

Six-year risk of first prescription of metformin in study groups compared to control group

			Univariable analysis			Multivariable analysis*,†
	Total	Metformin (%)	HR	95% CI	p Value	HR	95% CI	p Value
Cohort
Diclofenac	7140	84 (1.2)	1.00			1.00
TB	5769	85 (1.5)	1.25	0.93 to 1.70	0.142	1.59	1.15 to 2.20	0.005
AAC	6565	150 (2.3)	1.95	1.50 to 2.55	<0.0001	2.32	1.74 to 3.09	<0.0001
Statin	12 612	391 (3.1)	2.66	2.10 to 3.37	<0.0001	3.31	2.56 to 4.30	<0.0001

*Cox regression.

†Adjusting for: age, sex and ethnicity.

AAC, ACE inhibitors, angiotensin II receptor blockers, calcium channel blockers; TB, thiazides and β-blockers.