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. 2013 Nov 26;7:188. doi: 10.3389/fncir.2013.00188

Figure 2.

Figure 2

Influence of synaptic release and GAT-1 activity on ITonic(GABA). Recording conditions and supplements as in Figure 1A. (A,B) Results from two different types of HD mice. TTX (1 μM) reduces ITonic(GABA) without abolishing the HD-related difference. Block of GAT-1 with NO-711 (10 μM) increases ITonic(GABA). Note significantly stronger effect of NO-711 in HD mice (filled bars). In both graphs, the data sets of the 6 columns were independent, not paired. In the 3 groups for Control, TTX, and TTX+NO-711 the means from WT vs. HD were compared according to Mann–Whitney tests (see Table 1 for more details). In addition, we have performed Kruskal–Wallis statistics (KWS) to compare the differences between Control, TTX, and TTX plus NO-711 in WT and HD. The respective values were as follows. Q175 WT: KWS = 15.23, p < 0.001; Q175 HD: KWS = 50.91, p < 0.0001. R6/2 WT: KWS = 12.40, p < 0.01; R6/2 HD: KWS = 23.94, p < 0.0001. The asterisks denote: *p < 0.05, **p < 0.01, and ***p < 0.001.