Table 1.
Characteristics of I(Tonic)GABA in two mouse models of HD.
| WT | HD | p | |||||
|---|---|---|---|---|---|---|---|
| Mean | ±SE | N | Mean | ±SE | N | ||
| Q175 SERIES 1 | |||||||
| Standard | 30.7 | 2.6 | 30 | 21.9 | 2.1 | 37 | 0.0028 |
| + TTX 1 μM | 17.9 | 2.1 | 15 | 11.7 | 1.2 | 23 | 0.0016 |
| + TTX + NO-711 10 μM | 43.2 | 6.9 | 12 | 68.0 | 8.3 | 18 | 0.0306 |
| Q175 SERIES 2 | |||||||
| + TTX 1 μM | 34.1 | 4.2 | 12 | 16.9 | 1.5 | 13 | 0.0003 |
| + TTX + SNAP5114 40 μM | 22.9 | 3.2 | 13 | 35.0 | 4.2 | 7 | 0.0771 |
| + TTX + D-Asp 0.1 mM | 32.7 | 5.4 | 15 | 38.0 | 4.5 | 18 | n.s. |
| R6/2 | |||||||
| Standard | 36.1 | 5.2 | 11 | 15.7 | 3.0 | 14 | 0.0018 |
| + TTX 1 μM | 16.1 | 3.2 | 9 | 4.7 | 2.2 | 9 | 0.0078 |
| + TTX + NO-711 10 μM | 55.4 | 10.6 | 11 | 83.8 | 11.0 | 11 | 0.0648 |
| + TTX + D-Asp 0.1 mM | 12.4 | 1.6 | 11 | 15.9 | 3.9 | 13 | n.s. |
The significance levels of the differences between means from WT and HD apply to Mann–Whitney tests.