Various neuromodulation techniques are currently investigated in chronic migraine, but note that, as of to date, there is no approved indication for neuromodulation with electric or magnetic stimulation for episodic migraine. We suggest to investigate these techniques also in episodic migraine and to use quantitative models and modern control theory to determine an optimal stimulation protocol, target structure and phase within the migraine cycle. Photograph top left (SPG stimulation): courtesy Autonomic Technologies, Inc. © 2013. Inset figure top right: courtesy of STX-Med © 2013. Photograph bottom right (TMS device): courtesy of Neuralieve, Inc. © 2013 (trading as eNeura Therapeutics).