Table 5.

Regions of Significant Activation during Recombined Pair Correct Rejections

			MNI coordinates
Region of interest	Hemisphere	BA	x	y	z	t value	p value
Control group
Caudate	L	na	−14	4	22	5.73	0.000
Middle frontal gyrus	L	11	−34	48	−8	4.36	0.000
		8	−46	20	44	4.32	0.000
		47	50	48	−8	4.17	0.001
Thalamus	L	na	−16	−36	12	4.26	0.000
			0	−4	20	3.48	0.002
Precentral gyrus	R	6	58	−4	22	3.77	0.001
Low concussion group
Supramarginal gyrus	R	40	66	−46	30	4.88	0.000
Inferior parietal lobe	R	40	58	−46	28	3.70	0.001
			46	−52	54	3.82	0.001
High concussion group
Middle temporal gyrus	R	21	44	8	−38	5.30	0.000
Caudate	L	na	−18	−38	20	4.37	0.000
	R		16	−18	32	3.39	0.002
Insula	L	13	−36	−50	20	4.37	0.000
		13	−28	−10	26	3.54	0.002
Anterior cingulate	L	24	0	30	−4	4.05	0.001
Superior temporal gyrus	L	22	−60	−14	2	4.01	0.001
	R		46	−40		3.83	0.001
Supramarginal gyrus	L	40	−54	−52	30	3.68	0.001
Inferior parietal lobe	R	40	66	−38	28	3.29	0.003
Low concussion group>high concussion group
Supramarginal gyrus	R	40	58	−54	32	3.57	0.001
Effect of accuracy: low concussion group>high concussion group
Precentral gyrus	R	6	44	−4	36	6.34	0.000
		4	16	−32	74	3.37	0.001
		9	40	6	42	3.72	0.001
	L	4	−24	−28	48	4.14	0.000
Inferior frontal gyrus	R	44	52	2	22	4.29	0.000
Postcentral gyrus	R	3	28	−38	68	5.24	0.000
		3	12	−42	70	3.69	0.001
	L	3	−28	−38	62	3.53	0.001
Superior frontal gyrus	R	6	10	−10	74	4.78	0.000
		9	20	42	38	2.95	0.004
	L	6	−16	−14	70	3.16	0.002
Middle frontal gyrus	R	6	26	0	66	4.25	0.000
		6	42	8	52	4.06	0.000
		8	30	16	50	3.36	0.001
Superior parietal lobule	L	5	−18	−46	68	4.54	0.000
	R	41	42	−38	16	4.27	0.000
Middle temporal gyrus	L	22	−48	−42	−4	4.06	0.000
		39	−34	−68	20	3.49	0.001
	R	39	44	−66	18	3.33	0.001
Posterior cingulate	R	31	18	−38	46	3.94	0.000
		31	4	−24	46	3.84	0.000
		31	10	−30	38	3.18	0.002
Medial frontal gyrus	R	9	20	34	36	3.81	0.000
		6	4	−10	64	3.21	0.002
		6	14	−26	58	3.20	0.002
Anterior cingulate	L	32	−22	16	34	3.62	0.001
High concussion group>low concussion group
Paracentral lobe	R	6	10	−28	56	4.67	0.000
Inferior parietal lobe	L	40	−32	−46	46	4.27	0.000
Caudate	L	na	−20	−40	18	4.20	0.000
	R		22	−20	24	3.75	0.000
			28	−40	10	3.06	0.001
			10	10	20	3.44	0.001
Insula	R	13	28	−38	22	4.05	0.000
	L	13	−32	−34	20	3.53	0.001
Thalamus	R	na	16	−32	16	3.06	0.003
			14	−22	22	3.31	0.001
Anterior cingulate	R	24	18	−4	44	4.01	0.000
Postcentral gyrus	R	3	30	−26	40	3.58	0.001
Posterior cingulate	L	23	−6	−14	30	3.50	0.001
Precentral gyrus	R	6	42	−4	38	3.43	0.001
Medial frontal gyrus	L	6	−2	−18	66	3.41	0.001
Superior temporal gyrus	L	22	−38	−58	14	3.32	0.001
Precuneus	L	19	−34	−74	34	2.96	0.003
Effect of accuracy: high concussion group>low concussion group
Middle temporal gyrus	R	38	36	12	−42	3.22	0.002
Regions associated with a lesser number of reported concussions
No significant clusters
Regions associated with a greater number of reported concussions
No significant clusters
Low and high concussion groups
Inferior parietal lobe	R	40	66	−44	30	4.01	0.001
Middle temporal gyrus	R	21	46	6	−38	3.15	0.004

Regions significant at threshold of p<0.005 (uncorrected at the voxel level); k≥10.

BA, approximate Brodmann Area. Control, 0 concussions; low concussion, 0, 1, or 2 concussions; high concussion, 3 or more concussions.

MNI, Montreal Neurological Institute.