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SREBPs are host genes to conserved intronic miRNAs, miR-33a/b, which are co-expressed with SREBPs. Human SREBP-1 (A) and SREBP-2 (B) genes harbor related intronic miRNAs (miR-33b and miR-33a, respectively). The sequences encoding the pri-miRNAs are shown, with the mature miRNA sequences highlighted in red. C-E Expression profile of miR-33a/b and SREBP host genes in selected human tissues. Error bars represent experimental S.D.
