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. Author manuscript; available in PMC: 2013 Nov 26.
Published in final edited form as: Science. 2010 May 13;328(5985):10.1126/science.1189123. doi: 10.1126/science.1189123

Figure 4.

Figure 4

Regulation of HDL by miR-33a in vivo. A. Tail vein injection of mice fed a western-type diet with Locked Nucleic Acid (LNA)-antisense oligonucleotides directed against mouse miR-33a results in elevated total serum cholesterol. B. FPLC analysis of pooled serum from 5 mice on a western-type diet treated revealed an increase in the magnitude of the HDL-cholesterol peak in the LNA-antimiR-treated animals. Elution of lipoprotein standards is indicated by the labels. Plasma triglycerides (C), glucose (D), AST (E), and ALT (F) were unaffected by the treatments. Error bars represent s.e.m. ** denotes p<0.01.