Table 1.
Baseline patient characteristics, study design and study endpoints
| Hudson et al.13 1990 | P’ng et al.15 1993 | Witjes et al.16 1993 | Rogerson14 1994 | Heiner et al.12 2008 | Gee et al.11 2008 | Boorjian et al.10 2009 | |
|---|---|---|---|---|---|---|---|
| Study years included | Dec 1981–June 1989 | 1985–1990 | Apr 1987–Dec 1991 | Dec 1987–Oct 1991 | Dec 1999–July 2004 | June 1991–Sep 2003 | July 1978–Nov 2006 |
| Study type Institution | Retrospective
|
Retrospective
|
Retrospective
|
Retrospective Heidelberg Repatriation Hospital |
Retrospective
|
Retrospective
|
Retrospective
|
| Province/country | Missouri, USA | Queensland, Australia | Netherlands | Victoria, Australia | Georgia, USA | Wisconsin, USA | New York, USA |
| Total patients | 162 | 45 | 313 | 56 | 58 | 154 | 1218 |
| Included patients | 149 | 45 | 183 | 38 | 58 | 43 | 907 |
| Inclusion selection criteria | Available medication record | All patients included | N/A | Available medication record | N/A | Available records |
|
| Anticoagulant G1 | 29 | 9 | 42 | 13 | 7 | 20 | 221 |
| Control G2 | 120 | 36 | 141 | 25 | 51 | 23 | 686 |
| Male: Female ratio Statistical significance | N/A | 33:12 | N/A | N/A | N/A | 36:7 More males in G1 (NS) |
721:186 More males in G1 (p < 0.01) |
| Age, years (range) Statistical significance | N/A | Mean both groups: 69 (36–92) | N/A | N/A | N/A | Mean
p < 0.01 |
Median
p < 0.01 |
| Follow-up (range) | Mean
|
Mean both groups 20.3 months Median both groups 16 months (3–56) |
Mean
|
Mean varied among stages ranging from 6 to 28 months (2-36) | N/A | N/A | Median 4.2 years in patients without recurrence and 3.7 years without progression |
| Primary endpoint studied | Tumour recurrence | Persistent or recurrence tumour at first follow-up in 3 months | Disease (recurrence) free interval | Persistent or recurrence disease at 6 weeks | Response to therapy categorized in relation to age
|
Recurrence-free and progression-free intervals | Tumour recurrence and progression to open surgery |
G: group; N/A: not available