Table 3.
Effect of turmerone on the concentrations (ng/g tissue) of monoamines and their metabolites in the hippocampus of mice brain
| Group | NE | MHPG | DA | DOPAC | 5-HT | 5-HIAA | 5-HIAA/5-HT |
|---|---|---|---|---|---|---|---|
| Normal |
290.6 ± 23.8 |
244.4 ± 14.9 |
50.1 ± 2.0 |
31.9 ± 0.7 |
406.5 ± 14.7 |
198.9 ± 3.5 |
0.51 ± 0.03 |
| Control + FST |
220.3 ± 10.3 |
257.0 ± 11.8 |
41.9 ± 1.4 |
38.0 ± 1.1 |
216.6 ± 5.5### |
216.1 ± 9.6 |
1.01 ± 0.07### |
| Fluoxetine 10 mg/kg + FST |
299.7 ± 5.2 |
243.0 ± 5.3 |
49.6 ± 1.4 |
31.0 ± 1.8 |
400.0 ± 5.2*** |
194.0 ± 6.2 |
0.49 ± 0.02*** |
| Turmerone 2.5 mg/kg + FST |
398.0 ± 31.8*** |
228.0 ± 15.2 |
82.7 ± 2.0*** |
31.5 ± 0.9 |
489.1 ± 12.1*** |
176.8 ± 13.7 |
0.37 ± 0.03*** |
| Turmerone 5.0 mg/kg + FST | 386.1 ± 11.9*** | 227.0 ± 18.8 | 60.4 ± 1.8*** | 31.5 ± 0.8 | 573.1 ± 20.5*** | 185.5 ± 24.9 | 0.32 ± 0.05*** |
Values were the means ± SEM (n = 10). ###p < 0.001 as compared with the normal group. ***p <0.001 as compared with the control + FST group. (One-way ANOVA followed by Scheffe’s test). NE: norepinephrine, MHPG: 3 methoxy-4-hydroxyphenylglycol, DA: dopamine, DOPAC: 3,4-dihydroxyphenylacetic acid, 5-HT: serotonin, 5-HIAA: 5-hydroxyindoleacetic acid.