Table 3.
Metabolites most strongly correlated with CRP level in patients with early arthritis in groups 1 and 2*
| Ranked importance | Metabolites identified in patient group 1 (ppm) | Metabolites identified in patient group 2 (ppm) |
|---|---|---|
| 1 | Choline (3.20, 3.22, 3.23) | LDL lipids (1.24–1.27) |
| 2 | LDL lipids (1.24–1.27) | Acetylglycine (2.03, 3.71, 3.76) |
| 3 | Lactate (1.31, 1.33, 4.11) | Glucose (3.24–3.26, 3.41, 3.48, 3.68–3.69, 3.88) |
| 4 | Acetylglycine (2.03, 3.71, 3.76) | Fatty acids (0.8–0.84, 2.22–2.24) |
| 5 | Urea (5.77, 5.78, 5.79, 5.80, 5.81, 5.82) | Methylguanidine (2.81) |
| 6 | Glucose (3.24–3.26, 3.41, 3.48, 3.68–3.69, 3.88) | Lactate (1.31, 1.33) |
| 7 | Methylguanidine (2.81) | Threonine (3.58) |
| 8 | Methylhistidine (3.70) | Homocysteine (3.86) |
| 9 | Cholesterol (0.91) | Glycine (3.55) |
| 10 | Taurine (3.42) | Taurine (3.42) |
| 11 | Threonine (3.58) | Methylxanthine (3.49) |
| 12 | Fatty acids (0.8–0.84, 2.22–2.24) | Choline (3.20, 3.22, 3.23) |
| 13 | Methylxanthine (3.49) | Methylhistidine (3.70) |
| 14 | Homocysteine (3.86) | Cholesterol (0.91) |
*
Metabolites were identified using the partial least-squares regression analysis model and represent the regions of the spectra which had the greatest influence on the correlation with C-reactive protein (CRP) level. Values in parentheses are the nuclear magnetic resonance chemical shifts (in parts per million), which identify the location of the major peaks in the spectra. LDL = low-density lipoprotein.