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. 2013 Nov 26;4:322. doi: 10.3389/fphys.2013.00322

Figure 6.

Figure 6

Balanced cytoplasmic J+H and sarcolemmal J+H at steady-state pHi in normal and cAVB myocytes. (A) Steady-state pHi values were obtained in normal (open bars) and cAVB (filled bars) myocytes either under HEPES or CO2/HCO−3-buffered conditions. Significant differences (P < 0.01), the number of animals (N) and observations (n) are indicated. (B) Total sarcolemmal J+H of the acid extruders and the acid loaders are plotted against their pHi in one graph to visualize their overlap at the steady-state pHi. J+H of the acid extruders and acid loaders are balanced in normal myocytes at pHi 7.01 (B, left panel) and in cAVB myocytes at pHi 7.07 (B, right panel), causing respectively a sarcolemmal J+H of 8.5 and 15 amol/μm2/min at these pHi values.