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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Exp Gerontol. 2013 Aug 13;48(11):10.1016/j.exger.2013.08.001. doi: 10.1016/j.exger.2013.08.001

Figure 2. Endothelium dependent dilation in normal chow and western diet fed mice after antioxidant treatment.

Figure 2

Dose responses to acetylcholine in the absence or presence of the superoxide dismutase mimetic, TEMPOL, in young (Y, N=9/diet) (A) and old (O, N=8/diet) (B) normal (NC) and western diet (WD) fed mice. Dose responses to acetylcholine (ACh) in the absence or presence of the superoxide dismutase mimetic, TEMPOL, with and without treatment with the nitric oxide synthase inhibitor, L-NAME in young (C) and old (D) NC and WD fed mice. Maximal vasodilation to acetylcholine in young (E) and old (F) NC and WD fed mice. * Denotes difference from NC, † Denotes difference from WD § Denotes difference with L-NAME from ACh alone. Differences in dose responses were assessed by Repeated Measures ANOVA. Maximal vasodilation was determined for each dose response curve and a two-way ANOVA with Tukey post hoc was used to determine differences. Data are means±SEM, P≤0.05