Table 2.
Acetylcholinesterase Activity During Methamidophos Dose Selection (sc Injected) and at Different Time Points After the Selection of the IntD for the Remainder of the Study
| Dose selection (AChE inhibition at PN10) | |||
|---|---|---|---|
| LowD | IntD | HighD | |
| Cortex | −3.5±3.1 | −19.9±1.7*** | −33.4±1.6*** |
| Brainstem | −9.8±2.9** | −18.7±2.3*** | −26.2±2.1*** |
| AChE inhibition using the IntD | |||||
| PN3 (first injection) | PN9 (last injection) | PN63 (adulthood) | |||
| 1h after injection | 4h after injection | 1h after injection | 4h after injection | ||
| Cortex | −43.4±6.6** | −41.6±4.3** | −53.8±10.3** | −67.2±6.8** | −4.5±2.1 |
| Brainstem | −29.3±7.6** | −50.2±3.6*** | −52.3±5.4*** | −53.5±3.6** | −3.1±2.7 |
Note. Data presented as percent change from control values. Bold indicates the dose chosen to be used in the next set of experiments. HighD (3mg/kg), IntD (1mg/kg), LowD (0.25mg/kg).
**p < 0.01, ***p < 0.001, versus respective control group.