Table VII.
Comparison of Optimized Porous (F4) and Nonporous (NF4) Film of Glibenclamide
Parameters | Porous film (F4) | Nonporous film (NF4) |
---|---|---|
Swelling index after 120 min | 51.26 ± 0.70 | 35.71 ± 0.70 |
Mucoadhesion time (min) | 539.11 ± 3.05 | 510.00 ± 2.00 |
Mucoadhesive force (N) | 0.24 ± 0.04 | 0.20 ± 0.05 |
% Cumulative drug release at 8 h | 84.47 ± 0.94 | 62.66 ± 0.87 |
% Cumulative drug permeated at 8 h | 68.33 ± 0.67 | 53.47 ± 0.78 |
Release kinetics | Zero order | Peppas |
Correlation between in vitro drug release and ex vivo drug permeation (r 2) | 0.9931 | 0.9846 |