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. 2013 Sep 4;14(4):1360–1366. doi: 10.1208/s12249-013-0026-2

Table I.

Mid-points of Thermal Transition for Under Different Solution Conditions for aCgn (1 mg/mL)

aCgn
Solution conditions T m.u (°C) T m.agg (°C)
20 mM Citrate Buffer (100 mM NaCl; pH 4.6) 56.2 57.4
20 mM Citrate Buffer (100 mM NaCl; pH 3.5) 50.0 51.8
20 mM Citrate Buffer (100 mM NaCl; pH 2.5) 43.9 44.3
20 mM Citrate Buffer (pH 4.6) 56.6 58.3
20 mM Citrate Buffer (300 mM NaCl; pH 4.6) 55.2 56.8
20 mM Citrate Buffer (500 mM NaCl; pH 4.6) 55.2 56.5

aCgn α-chymotrypsinogen, T M.u temperatures for unfolding, T M.agg temperatures for aggregation