Table 3.

Univariate (n = 1,025) and Multivariable Adjusted (n = 947)^*† Associations between BNP Variables Dichotomized at the Top Quartile and Time to Heart Failure Hospitalization or Heart Failure Mortality after Primary Coronary Artery Bypass Graft Surgery

Perioperative BNP Variable		Proportion, n (%)	Unadjusted Hazard Ratio (95% CI)	Unadjusted P Value	Multivariable Adjusted† Hazard Ratio (95% CI)	Multivariable Adjusted† P Value	AlC of Multivariable Model* with BNP Included in Model*†
Top quartile preoperative BNP		257(25.1)	4.93 (3.34–7.27)	<0.001	2.60(1.63–4.14)	<0.001	1,182.75
Top quartile peak postoperative BNP		256 (25.0)	4.01 (2.73–5.89)	<0.001	1.74(1.08–2.78)	0.02	1,193.65
Preoperative BNP and Peak Postoperative BNP							1,184.93
Lower 3 quartiles	Lower 3 quartiles	669 (65.3)	1.00	Reference	1.00	Reference
Lower 3 quartiles	Top quartile	99 (9.7)	2.70(1.39–5.27)	0.003	1.66(0.81–3.40)	0.17
Top quartile	Lower 3 quartiles	100(9.7)	3.96(2.17–7.24)	<0.001	3.05(1.58–5.89)	<0.001
Top quartile	Top quartile	157(15.3)	7.27(4.61–11.46)	<0.001	3.06(1.72–5.44)	<0.001

^*Multivariable clinical model is shown in table 1 of Supplemental Digital Content 1, http://links.lww.com/ALN/A945. The AIC of the multivariable clinical model before adding BNP into the model = 1,196.90.

^†Seventy-eight subjects missing one or more of the variables in Supplemental Digital Content, table 1, http://links.lww.com/ALN/A945, are not included in the multivariable analysis.

AIC = Akaike information criterion; BNP = B-type natriuretic peptide.