Table 1.

Assessment of the clinical & angiographic outcomes

Assessment of the clinical outcome
		Aggravation	No change	Improvement
Claudication		Development of new ischemic foot lesion after WBMSC therapy	No statistically significant difference of the pain-free walking distance	Return to normal activity Statistically significant change of the pain-free walking distance
Critical ischemia	Ischemic rest pain	Development of new ischemic foot lesion after WBMSC therapy Any amputation	No change of ischemic rest pain	Relief of ischemic rest pain
	Tissue loss	Recurrence of a healed ischemic lesion Development of new ischemic foot lesion after complete wound healing Any amputation	No change of ischemic foot wound	Complete wound healing with or without planned debridement or amputation
Assessment of the angiographic outcome
	-2	-1	0	+1	+2
Recanalization of run-off vessels	≥50% progression of occlusion in the previous lengths of the run-off vessels	＜50% progression of occlusion in the previous length of the run-off vessels	No change of the overall extent of the run-off vessels	＜50% segmental recanalization in the previous lengths of the run-off vessels	≥50% segmental recanalization in the previous lengths of the run-off vessels
Angiogenesis	Any loss of firstorder collateral vessels	Any loss of second-order collateral vessels	No change of the overall extent of collateral vessels	Development of more than second-order collateral vessels	Development of first-order
Arteriogenesis	Decreased diameter and length of the pre-existing collateral vessels	Decreased diameter or length of the pre-existing collateral vessels	No change of the overall extent of collateral vessels	Increased diameter or length of the pre-existing collateral vessels	Increased diameter and length of the pre-existing collateral vessels