Table 3.
Concentration of cytokine and chemokine (pre-and post-) in serum from CP patients with either allogenic (n=3) or autologous (n=4)
| Allogeneic (N=3) | Autologous (N=4) | p-value | |||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Pre (pg/ml) | Post 24 h (pg/ml) | Difference | Pre (pg/ml) | Post 24 h (pg/ml) | Difference | ||
|
| |||||||
| IL-1aa | 29.69±33.86 | 24.94±28.38 | -4.75±5.54 | 147.15±189.88 | 155.3±204.22 | 8.14±16.02 | 0.04 |
| IL-6a | 23.81±3.94 | 8.89±10.29 | -14.92±9.07 | 59.53±77.27 | 60.13±80.01 | 0.61±4.52 | 0.04 |
| IL-15a | 10.72±2.4 | 12.73±2.29 | 2.01±0.5 | 107.42±140.18 | 104.41±139.6 | -3.01±4.02 | 0.05 |
| CCL5/RANTESa | 4,423.95±482.08 | 3,051.15±490.01 | -1,372.8±353.97 | 2,796.13±324.69 | 2,901.74±398.66 | 105.61±118.86 | 0.05 |
| TNFβa | 23.72±14.89 | 18.45±14.87 | -5.27±1.11 | 200.84±280.02 | 201.35±282.64 | 0.51±3.06 | 0.05 |
| CCL4/MIP-1β | 307.38±367.2 | 60.39±37.18 | -246.99±336.28 | 137.11±107.92 | 158.2±148.77 | 21.1±43.53 | 0.11 |
| IL-5 | 0.31±0.54 | 0.11±0.18 | -0.21±0.36 | 16.15±28.83 | 16.35±28.97 | 0.2±0.23 | 0.17 |
| CCL3/MIP-1α | 1,009.85±1,286.47 | 58.93±54.68 | -950.92±1,237.62 | 55.4±106.51 | 54.06±108.13 | -1.34±3.49 | 0.19 |
| sCD40L | 9,900.8±171.81 | 10,000±0 | -99.2±171.81 | 8,637.55±954.67 | 9,722.46±555.07 | 1,084.92±891.66 | 0.19 |
| IL-8/CXCL8 | 421.77±531.57 | 24.32±5.25 | -397.46±533.18 | 60.26±69.99 | 55.27±63.42 | -4.99±6.91 | 0.21 |
| IFNr | 31.86±36.83 | 8.91±2.88 | -22.95±34.5 | 163.65±281.49 | 169.24±305.21 | 5.59±26.15 | 0.21 |
| sIL-2Rα | 167.84±33.57 | 165.66±31.5 | -2.18±21.03 | 349.96±166.82 | 421.88±185.4 | 71.92±66.69 | 0.21 |
| Flt-3 Ligand | 58.54±34.3 | 27.95±4.75 | -30.59±32.8 | 139.97±186.59 | 143.61±185.08 | 3.64±8.73 | 0.21 |
| GM-CSF | 81.24±105.54 | 27.72±41.14 | -53.52±65.44 | 179.95±341.54 | 162.61±305.93 | -17.33±35.69 | 0.21 |
| IL-2 | 4.17±2.23 | 2.94±0.9 | -1.23±1.47 | 36.45±61.67 | 38.37±66.74 | 1.92±5.24 | 0.21 |
| IL-13 | 11.29±10.12 | 9.14±9.51 | -2.16±1.26 | 73.39±111.49 | 72.48±108.48 | -0.91±3.59 | 0.37 |
| EGF | 65.81±56.2 | 42.08±33.1 | -23.73±29.85 | 21.71±38.36 | 33.15±28.68 | 11.44±38.17 | 0.37 |
| VEGF | 218.84±175.58 | 73.41±5.29 | -145.42±172.97 | 437.95±769.7 | 412.26±673.76 | -25.69±100.2 | 0.37 |
| IL-17 | 4.37±5.61 | 0.41±0.72 | -3.96±4.92 | 84.45±158.13 | 79.84±143.8 | -4.61±15.1 | 0.52 |
| IL-1b | 8.62±14.92 | 0±0 | -8.62±14.92 | 72.58±117.46 | 73.58±119.79 | 1±2.43 | 0.55 |
| IL-9 | 0±0 | 0±0 | 0±0 | 5.48±10.96 | 4.77±9.54 | -0.71±1.42 | 0.56 |
| IFNa2 | 0±0 | 0±0 | 0±0 | 166.31±332.63 | 171.05±342.1 | 4.74±9.48 | 0.56 |
| G-CSF | 0±0 | 0±0 | 0±0 | 41.26±82.52 | 46.05±92.1 | 4.79±9.58 | 0.56 |
| PDGF-AB/BB | 10,000±0 | 10,000±0 | 0±0 | 10,000±0 | 9,187.66±1,624.68 | -812.34±1,624.68 | 0.56 |
| IL-4 | 5.57±9.01 | 2.09±3.63 | 3.48±5.39 | 88.46±151.91 | 92.01±141.74 | 3.55±19.07 | 0.58 |
| IL-10 | 34.66±4.47 | 34.07±17.48 | 0.59±14.29 | 158.22±235.78 | 157.5±237.87 | -0.72±2.18 | 0.59 |
| IL-12(p40) | 55.31±27.9 | 41.55±15.89 | 13.76±17 | 243.22±321.25 | 277.6±401.88 | 34.38±82.3 | 0.59 |
| CCL7/MCP-3 | 87.21±45.21 | 83.13±45.43 | 4.09±3.01 | 253.1±324.63 | 244.48±319.72 | -8.62±12.56 | 0.59 |
| TNFα | 22.31±19.58 | 7.79±3.11 | 14.52±16.74 | 18.72±25.2 | 17.66±26.11 | -1.06±0.94 | 0.59 |
| CCL2/MCP-1 | 468.39±75.59 | 437.75±51.21 | 30.64±126.3 | 890.61±495.35 | 819.58±523.94 | -71.03±146.34 | 0.85 |
| CCL11/Eotaxin | 78.93±26.87 | 77.01±39.15 | 1.92±12.86 | 101.47±103.04 | 103±87.51 | 1.53±23.89 | 0.85 |
| CCL22/MDC | 2,545.56±310.98 | 2,176.97±368.79 | 368.59±239.21 | 2,762.14±511.62 | 2,362.79±408.48 | -399.35±312.24 | 0.85 |
| CX3CL1 | 126.5±91.12 | 116.07±67.11 | 10.44±35.54 | 714.94±918.12 | 704.45±968.69 | -10.49±55.24 | 0.85 |
| /Fractalkine | |||||||
| TGFα | 19.97±7.22 | 18.35±4.25 | 1.62±3.55 | 72.55±114.19 | 71.61±107.82 | -0.94±8.42 | 0.85 |
| IL-1ra | 100.6±72.77 | 71.25±13.83 | 29.35±59.65 | 329.54±460.32 | 324.54±441.13 | -5±20.85 | 1 |
| IL-3 | 0±0 | 0±0 | 0±0 | 0±0 | 0±0 | 0±0 | 1 |
| IL-7 | 0±0 | 0±0 | 0±0 | 30.82±59.53 | 30.67±58.2 | 0.15±1.55 | 1 |
| IL-12(p70) | 7.14±2.13 | -5.74±1.26 | -1.4±2.65 | 80±143.97 | 74.42±132.48 | 5.58±11.53 | 1 |
| CXCL1/GROα | 792.65±333 | -814.92±302.73 | 22.27±54.61 | 896.52±358.54 | 955.57±287.98 | -59.05±114.21 | 1 |
| CXCL10/IP-10 | 237.07±27.65 | -212.79±55.96 | 24.27±74.31 | 270.85±79.38 | 230.76±73.59 | 40.09±42.78 | 1 |
| FGF-2 | 123.82±76.46 | -75.53±17.69 | 48.29±59.32 | 406.61±634.33 | 376.09±614.75 | 30.51±28.35 | 1 |
| PDGF-AA | 7,682.55±1493.7 | 8,020.52±487.87 | 337.97±1,124.51 | 6,461.26±2,424.62 | 6,645.9±2,984.82 | 184.64±1,116.36 | 1 |