Skip to main content
. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Eur J Neurosci. 2013 Sep 23;38(10):10.1111/ejn.12361. doi: 10.1111/ejn.12361

Fig. 4.

Fig. 4

Extracellular dopamine released in (A) the nucleus accumbens in control (n = 13), limited-access (n = 8) and extended-access (n = 15) groups; and (B) in the caudate-putamen in control (n = 12), limited-access (n = 7) and extended-access (n = 14) groups. Results are expressed as changes in dopamine compared with the percentage of median baseline. The extended-access group exhibited tolerance to the effects of METH on dopamine release compared with the control group and the limited-access group in the (A) nucleus accumbens but not (B) the caudate-putamen (*P < 0.05, between groups; §P < 0.05, compared with baseline). The data are expressed as mean ± SEM. Baseline dopamine levels (nm) were: in the nucleus accumbens, 16.7 ± 2.5, 23.1 ± 5.1 and 16.6 ± 2.8; and in the caudate-putamen, 52.7 ± 8.0, 35.8 ± 4.1 and 59.2 ± 22.9 for control, limited-access and extended-access groups, respectively.