Table 6.
Regulatory pathways altered by stretch, BIRB796 or combined treatment
| Pathway enrichment by stretch | |
| Cytoskeleton remodeling | TGF, WNT, and cytoskeletal remodeling* |
| Development | Regulation of epithelial-to-mesenchymal transition |
| Development | WNT signaling pathway Part 2 |
| Cytoskeleton remodeling | Neurofilaments |
| Immune response | IL-1 signaling pathway* |
| Cytoskeleton remodeling | Cytoskeleton remodeling* |
| Development | Hedgehog signaling |
| Cytoskeleton remodeling | Regulation of actin cytoskeleton by Rho GTPases |
| Cytoskeleton remodeling | Reverse signaling by ephrin B |
| Normal and pathological | TGF-beta-mediated regulation of cell proliferation* |
| Pathway enrichment by BIRB796 | |
| Development | WNT signaling pathway Part 2 |
| Cell adhesion | Cell matrix glycoconjugates |
| Cytoskeleton remodeling | TGF, WNT, and cytoskeletal remodeling* |
| Development | Notch signaling pathway |
| Development | Regulation of epithelial-to-mesenchymal transition |
| Cell adhesion | Ephrin signaling |
| Cell adhesion | Tight junctions |
| Development | A2B receptor: action via G-protein alpha s* |
| Cell adhesion | Chemokines and adhesion |
| Chemotaxis | Leukocyte chemotaxis |
| Pathway enrichment by stretch + BIRB796 | |
| Development | Regulation of epithelial-to-mesenchymal transition |
| Chemotaxis | Leukocyte chemotaxis |
| Cell adhesion | Cell matrix glycoconjugates |
| Immune response | Role of HMGB1 in dendritic cell maturation and migration* |
| Cytoskeleton remodeling | Keratin filaments |
| Cell adhesion | Plasmin signaling* |
| Cell adhesion | Chemokines and adhesion |
| Immune response | Immunological synapse formation |
| Cell adhesion | Tight junctions |
| Cell adhesion | Ephrin signaling |
*
P < 0.05 change in p38 MAP kinase pathway-related transcripts.