Table 7.

Transcription factor binding sites (and number per gene) for selected genes noted to alter transcription in response to stretch, BIRB796, or stretch + BIRB796

TF binding sites	AREG	EREG	IL1RL1	PTGS2	MYH3	MYBPC1	MAPK3K6	FOSL1	MAPK12	FGF8	REG3A
AP-1 (Lal et al. 2008; Lee et al. 2011)	3	3	1		2		2	5	2	2
AREB6	1			1	1	1	4	1	2	3	1
ATF-2 (Monzen et al. 2001; Li et al. 2011)	1			1				2	1
cdc5	1	1	1	1
C-Jun (Lal et al. 2008; Lesman et al. 2010)	2	1			2		2	5	1	7
CREB (Li et al. 1999; Stevens et al. 2009; Streicher et al. 2010; Turner et al. 2010)	1				2		3	5	7	6
Evi-1 (Sengupta et al. 2013)				2	1	1		1	2	2	1
FOXD1 (Liang and Molkentin 2003; Liang et al. 2010)	2	1		2		1
FOXJ2 (Liang and Molkentin 2003; Liang et al. 2010)	1	1	1	2			1			4
GATA-1			2		2	2	3	6	2	6
GATA-2			1				1	1		1
GATA-3			2				1	1		1
HOXA9 (Markou et al. 2004)		1	1					1		3
IRF-1 (Maron et al. 2001)		1					1			1
MEF-2A (Park et al. 2008; Rubbens et al. 2009)	2		2			5				6
MyoD			1		1		2	3
NF-kB				1			1	4		2
Nkx2.5	1	2	1		1	2		2	2	1
p300 (Nakamura et al. 2013)								2	1	1
p53		1			1	1	3	4	1	4
Pax-4a	1		1	1	2	1	3	4	1	7
Pax-6				1	1	2	2	4	2	2	1
POU2F1	3	1		1		3		1	1	7
POU3F2						1			1	2
PPAR (Schaaf et al. 2011; Schueler et al. 2012; Sekiya et al. 2013)				1	1	1	1	5	2	2
SEF-1	1			1			3	1	1
SREBP-1a (Seko et al. 1999)	1	1		2	1		3	1	1	1	1
SREBP-1b (Seko et al. 1999)	1	1		2	1		3	1	1	1	1
SREBP-1c (Seko et al. 1999)	1	1		2	1		3	1	1	1	1
SRF			1	1	1	1	2	2	1	4
STAT3 (Monzen et al. 2001; Nadruz et al. 2005)					1					1
STAT5A (Kuma et al. 2005; Kurazumi et al. 2011; Sato et al. 2011)	1			1	2	1	3	1	3	2
YY1 (Qiu et al. 2008; Puthanveetil et al. 2013)			1		1		1	5