Table 2.
Clinical and functional characteristics of patients
| Variables | Controls (n = 7) | Nonhypoxemic COPD (n = 7) | Hypoxemic COPD (n = 6) | P-values |
|---|---|---|---|---|
| Age, years | 59 ± 3.4 | 58 ± 4.2 | 60 ± 3.3 | NS1,2,3 |
| Male/female | 4/3 | 5/2 | 4/2 | – |
| Tobacco, packet-year | 0 | 32 ± 2.3 | 41 ± 2.8 | <0.053 |
| FEV1,% pred | 91 ± 2.6 | 82 ± 3.8 | 68 ± 4.5 | <0.051; <0.012; <0.053 |
| FEV1/FVC,% | 84 ± 2.3 | 65 ± 1.5 | 61 ± 2.4 | – |
| DLCOc,% pred | 88 ± 3.5 (n = 4) | 90 ± 4.5 (n = 4) | 74 ± 5.8 (n = 3) | NS1; <0.052,3 |
| Pao2, mmHg | 90 ± 1.9 | 84 ± 2.6 | 70 ± 2.0 | NS1; <0.0012; <0.013 |
| Paco2, mmHg | 38 ± 1.9 | 40 ± 1.9 | 42 ± 1.6 | NS1,2,3 |
| sPAP, mmHg | 30 ± 1.8 (n = 5) | 29 ± 2.2 (n = 5) | 31 ± 1.5 (n = 4) | NS1,2,3 |
| ET-1, fmol/mL | 1.43 ± 0.26 | 3.42 ± 0.63 | 6.16 ± 0.83 | <0.011; <0.0012; <0.053 |
% pred, percentage of predicted value; FEV1, forced expiratory volume in 1 sec; FVC, forced vital capacity; DLCOc, diffusing capacity of monoxide carbon corrected with hemoglobin; sPAP, systolic pulmonary arterial pressure; ET-1, endothelin-1; NS, no significant difference.
1
nonhypoxemic COPD versus controls
2
hypoxemic COPD versus controls
3
hypoxemic COPD versus nonhypoxemic COPD