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. 2013 Nov 26;8(11):e81276. doi: 10.1371/journal.pone.0081276

Table 3. Chromosomal bands most affected in present study, genes and recurrent chromosomal reorganization present in hematopoietic malignances, and comparising with chronic benzene exposure.

Chromosomal Bands Cellular cycle control DNA repair   Oncogenes   Tumor suppressors Apoptosis   Type of Cancer Individuals exposed chronically to benzene References
2q21 CCNT2 ERCC3 CH-Ras CXCR4 - T-Cell lymphoma No [31]
NMTC1, TP21 Chronic lymphocytic leukemia (CLL) No [40]
3q27 - - - BCL6 - T-Cell lymphoma No [31]
Non-Hodgkin lymphoma (NHL) No [41]
5q31 CDC23 - TGFBI IRF1 DND1 Acute lymphoblastic leukemia (ALL) No [32]
CDC25 EGR1 Myelodysplastic Syndrome (MDS) Yes [42]
CDKL3 Chronic myelomonocytic leukemia (CMML) No [43]
Myelodysplastic Syndrome No [44]
Acute myeloid leukemia (AML) and myelodysplastic Syndrome (MDS) No [45]
Acute lymphoblastic leukemia (ALL) No [46]
11q23 - - - - - Leukemogenesis (ALL and AML) No [47]
Acute lymphoblastic leukemia (ALL) No [32]
Acute lymphoblastic leukemia (ALL) Yes [23]
Acute lymphoblastic leukemia (ALL) No [30]
5q31/11q23 - - - - - Acute myeloid leukemia (AML) Yes [33]