Table 1. Zinc-induced pancreatic pathology in control and Zip5 ^{Panc KO} mice.

Genotype	Large Cytoplasmic Vacuoles	Peripancreatic Inflammation
Zip5panc KO	No	severe
	Yes	moderate
	Yes	severe
	Yes (prominent)	severe
	Yes (prominent)	severe
	Yes (prominent)	severe
	Yes	severe
	No (atrophy of acinar cells)	severe
	No (atrophy of acinar cells)	severe
Control	No	mild to moderate
	No	moderate
	No	moderate
	No	moderate

Newly weaned mice were injected with tamoxifen to induce Zip5 recombination in pancreatic acinar cells by activation of Cre:ERT2 expressed from an ela-Cre-ERT2 transgene. Two weeks after the last tamoxifen injection, control (Control) littermates and pancreas-specific Zip5-knockout (Zip5 ^{Panc KO}) were given an I.P. injection of zinc sulfate (6.25 mg zinc/kg body weight) and 24 h later pancreata were harvested and paraffin sections were prepared, stained with hematoxylin and eosin and evaluated blind by a pathologist. Each row represents an individual animal.