Figure 7. Spatial learning and memory in the Morris water maze.

(A) The average escape latency improved across the training trails in all genotypes, but especially on days one to three, the BKα^−/− mice improve less within the training sessions. Note that on the last training trail on day 4 they caught up and performed as well as the WT mice. (B) Escape latency as a function of days of experience with the task. The average escape latency for each day was fitted with a one component exponential function for each genotype and time constants were derived from the resulting functions. The BKα^−/− mice have a longer time constant then the WT and the BKα^+/− mice. (C) Performance on the probe day. All mice spend a significant higher amount of time in the quadrant where previously the platform was hidden (target, solid dark grey) than in any other quadrant. The dashed line indicates 25% chance criterion.