Figure 2. Whole-cell sodium currents of slowed hNa_v1.4 inactivation in presence of toxin or following MTS modification.

The channels are activated by 40 ms depolarization in 5 mV increments from −90 to +65 mV. (A) R3C; (B) R3C with 100 nM LqhαIT in bath solution incubated at room temperature for 30 min prior to patching the cell. (C) R3C after 10 min treatment with 20 µM extracellular MTSET (cysteine side-chain modification is complete). HP −120 mV.