Table 2. Parameter distributions for uncertainty and sensitivity analysis.
| ParameterName | Distribution1 | Argument 12 | Argument 2 |
|---|---|---|---|
| GeneralMortalityRate | U | 5.75 ⋅ 10-5 | 1.73 ⋅ 10-4 |
| TreatmentFailureRate | U | 0 | 5 ⋅ 10-3 |
| CD4AsymptomPhaseCutoff | D | 2 ⋅ 102 | |
| InitialUninfCD4 | N | 7 ⋅ 102 | 102 |
| InitialInfCD4 | D | 0.00 | |
| InitialViralLoad | U | 5 ⋅ 10-1 | 5 ⋅ 106 |
| TrPr_Acute | U | 4.4 ⋅ 10-2 | 8.6 ⋅ 10-2 |
| TrPr_1 | U | 5.4 ⋅ 10-4 | 10-3 |
| TrPr_2 | U | 5.9 ⋅ 10-3 | 1.2 ⋅ 10-2 |
| TrPr_3 | U | 6.4 ⋅ 10-3 | 1.3 ⋅ 10-2 |
| TrPr_4 | U | 7.4 ⋅ 10-3 | 1.5 ⋅ 10-2 |
| TrPr_5 | U | 1.2 ⋅ 10-2 | 2.4 ⋅ 10-2 |
| NumberUIAI_1 | G | 7.1 ⋅ 10-1 | 2.65 |
| NumberUIAI_2 | G | 7.1 ⋅ 10-1 | 1.15 |
| NumberUIAI_3 | G | 7.1 ⋅ 10-1 | 2.05 |
| NumberUIAI_4 | G | 7.1 ⋅ 10-1 | 7.8 ⋅ 10-1 |
| NumberUIAI_5 | G | 7.1 ⋅ 10-1 | 3.80 |
| NumberUIAI_6 | G | 7.1 ⋅ 10-1 | 1.57 |
| NumberUIAI_7 | G | 7.1 ⋅ 10-1 | 1.77 |
| MortalityRateOnTreatment_1 | U | 8 ⋅ 10-4 | 2.4 ⋅ 10-3 |
| MortalityRateOnTreatment_2 | U | 6.5 ⋅ 10-4 | 1.9 ⋅ 10-3 |
| MortalityRateOnTreatment_3 | U | 1.5 ⋅ 10-3 | 4.5 ⋅ 10-3 |
| MortalityRateOnTreatment_4 | U | 2.5 ⋅ 10-3 | 6.1 ⋅ 10-3 |
| MortalityRateOnTreatment_5 | U | 1.6 ⋅ 10-3 | 4.8 ⋅ 10-3 |
| MortalityRateOnTreatment_6 | U | 1.5 ⋅ 10-3 | 4.6 ⋅ 10-3 |
| p_eventImpr | U | 10-1 | 6 ⋅ 10-1 |
| p_eventCD4 | U | 5 ⋅ 10-1 | 1.00 |
| AddRateVLDecrease | U | 10-3 | 3 ⋅ 10-3 |
| RateCD4Increase | U | 6.67 | 20.0 |
| AddRateVLIncrease | U | 8 ⋅ 10-4 | 2.4 ⋅ 10-3 |
| c | U | 1.20 | 3.60 |
| sT | U | 1.5 ⋅ 102 | 4.5 ⋅ 102 |
| pT | U | 4.5 ⋅ 10-1 | 1.35 |
| Tmax | U | 7.5 ⋅ 102 | 2.25 ⋅ 102 |
| dT | U | 3 ⋅ 10-1 | 9 ⋅ 10-1 |
| k | U | 3.6 ⋅ 10-4 | 1.1 ⋅ 10-3 |
| delta | U | 3.60 | 1.08 ⋅ 101 |
| N | U | 6 ⋅ 102 | 1.8 ⋅ 103 |
| Mp | LN | 9.22 | 1.80 |
| p_eventImprAfterFailure | U | 0.00 | 5 ⋅ 10-1 |
| RateVLIncreaseAfterFailure | U | 1.7 ⋅ 10-4 | 5.1 ⋅ 10-4 |
| RateCD4DecreaseAfterFailure | U | 2.50 | 7.50 |
| RateCD4DecreaseAsymptom_1 | U | 1.51 | 4.53 |
| RateCD4DecreaseAsymptom_2 | U | 1.87 | 5.60 |
| RateCD4DecreaseAsymptom_3 | U | 2.30 | 6.90 |
| RateCD4DecreaseAsymptom_4 | U | 2.70 | 8.10 |
| RateCD4DecreaseAsymptom_5 | U | 3.19 | 9.56 |
| p_ART | N | 4 ⋅ 101 | 10 |
1
U(Uniform), N(Normal), G(Gamma), D(Deterministic)
2
For Uniform distribution, Argument1 is the minimum, Argument 2 is the maximum of the range
For Normal and LogNormal distributions, Argument1 is the mean, Argument 2 is the standard deviation
For Gamma distribution, Argument1 is the shape parameter, Argument 2 is the scale parameter