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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Crit Care Med. 2013 Dec;41(12):10.1097/CCM.0b013e318298a562. doi: 10.1097/CCM.0b013e318298a562

Figure 3. Analysis of thrombus formation in the dorsal skinfold chamber.

Figure 3

(A, B) Images (original magnification ×200) display patency of postcapillary venules prior to thrombus formation (upper panel) and standstill of perfusion upon light/dye-induced thrombus formation due to complete vessel occlusion (lower panel) in ZPI+/+ (A) or PZ+/+ (B) mice. (C, D) The occlusion times in venules upon induction of GSR or exposure to physiological saline are quantified for ZPI (C) or PZ (D) mouse strains. Data are given as box plots indicating the median with the 25th and 75th percentiles. Mann-Whitney rank-sum test, followed by Bonferroni correction; * p<0.05 vs. saline-treated mice with the same genetic background, # p<0.05 vs. wild-type GSR mice. Abbreviations: PZ, protein Z; ZPI, protein Z-dependent protease-inhibitor; GSR, generalized Shwartzman reaction; TI, thrombus induction. (GSR 4 hours: ZPI+/+ n=11, ZPI−/− n=14, PZ+/+ n=11, PZ−/− n=14; saline: ZPI+/+ n=11, ZPI−/− n=13, PZ+/+ n=12, PZ−/− n=12).