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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Crit Care Med. 2013 Dec;41(12):10.1097/CCM.0b013e318298a562. doi: 10.1097/CCM.0b013e318298a562

Figure 4. Analysis of thrombus formation in HE-stained liver tissue.

Figure 4

Representative images (A; original magnification ×100) display the magnitude of thrombus formation in liver tissue upon 8 hours of GSR (arrows). Thrombus formation is quantified as the fraction of occluded vessels in [%] of all vessels observed (B). Data are given as box plots indicating the median with the 25th and 75th percentiles. Mann-Whitney rank-sum test, followed by Bonferroni correction; # p<0.05 vs. wild-type GSR mice. Abbreviations: PZ, protein Z; ZPI, protein Z-dependent protease-inhibitor; GSR, generalized Shwartzman reaction; (GSR 8 hours: ZPI+/+ n=6, ZPI−/− n=7, PZ+/+ n=5, PZ−/− n=9).