Table 1.
Microhemodynamics in mice 4 hours after induction of GSR or exposure to physiological saline
| ZPI-mice | saline | GSR | |||
|---|---|---|---|---|---|
| ZPI+/+ | ZPI−/− | ZPI+/+ | ZPI−/− | ||
| n=11 | n=13 | n=11 | n=14 | ||
| median (IQR) | median (IQR) | median (IQR) | median (IQR) | ||
| arterioles |
velocity
[μm/s] |
948 (893-1011) | 943 (729-1047) | 642* (352-774) | 629* (475-696) |
| vbf [pL/s] | 898 (748-1112) | 829 (511-1025) | 580 (339-909) | 549 (253-694) | |
| γ [s−1] | 104 (85-122) | 115 (77-134) | 72 (40-100) | 74 (55-89) | |
| venules |
velocity
[μm/s] |
489 (249-628) | 546 (377-638) | 215 (76-337) | 202* (121-331) |
| vbf [pL/s] | 611 (285-876) | 550 (307-755) | 186 (58-401) | 227* (75-295) | |
| γ [s−1] | 61 (39-94) | 57 (41-78) | 25* (9-35) | 21* (16-30) | |
| PZ-mice | saline | GSR | |||
| PZ+/+ | PZ−/− | PZ+/+ | PZ−/− | ||
| n=12 | n=12 | n=11 | n=14 | ||
| median (IQR) | median (IQR) | median (IQR) | median (IQR) | ||
| arterioles |
velocity
[μm/s] |
858 (824-1025) | 1043 (720-1352) | 664 (437-788) | 597* (478-738) |
| vbf [pL/s] | 1088 (800-1290) | 1243 (1200- 1682) |
563* (431-649) | 743* (672-849) | |
| γ [s−1] | 86 (71-101) | 113 (66-121) | 73 (46-90) | 70 (45-78) | |
| venules |
velocity
[μm/s] |
617 (573-682) | 528 (492-613) | 149* (125-268) | 294* (172-337) |
| vbf [pL/s] | 954 (615-1273) | 670 (452-865) | 187* (109-362) | 310* (218-419) | |
| γ [s−1] | 62 (50-80) | 56 (49-68) | 22* (12-28) | 27* (14-36) | |
Data are given as median and IQR. Mann-Whitney rank-sum test, followed by Bonferroni correction;
*
p<0.05 vs. saline-treated mice with the same genetic background.
Abbreviations: ZPI, protein Z-dependent protease-inhibitor; PZ, protein Z; GSR, generalized Shwartzman reaction; velocity, blood flow velocity; vbf, volumetric blood flow; γ, wall shear rate; IQR, interquartile range.