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. 2013 Nov 22;8:4495–4506. doi: 10.2147/IJN.S52239

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© 2013 Chuang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Penh response to aerosolized methacholine measured (A) 1 day before AgNP/FA exposure and OVA challenge, and (B) 1 day after AgNP/FA exposure and OVA challenge in the control (FA-C and Ag-C) and allergic mice (FA-A and Ag-A). Penh response to 5 (M5), 10 (M10), and 25 mg/mL methacholine (M25) measured (C) 1 day after AgNP/FA exposure and OVA challenge, and (D) 1 day before and after AgNP/FA exposure and OVA challenge in the control and allergic mice.

Notes: Values are expressed as the mean ± standard deviation; n=5–6. ^#P<0.001; **P<0.01; *P<0.05.

Abbreviations: A, antigen; AgNP, silver nanoparticles; C, control; FA, filtered air; M, methacoline; OVA, ovalbumin; PBS, phosphate-buffered saline; Penh, enhanced pause.