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. 2013 Nov 22;8:4495–4506. doi: 10.2147/IJN.S52239

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© 2013 Chuang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Percentages of (A) BALF neutrophils, (B) lymphocytes, (C) eosinophils, and (D) macrophages recovered 2 days after AgNP/FA exposure and OVA challenge in control and allergic mice. (E) Photomicrographs (200×) of hematoxylin and eosin staining of the lungs from the control and allergic mice after AgNP/FA exposure and OVA challenge. In the control mice, AgNP exposure induced lymphocytic and neutrophilic inflammatory infiltration; in the allergic mice, AgNP/FA exposure resulted in lymphocytic and neutrophilic inflammation as well as the recruitment of eosinophils and macrophages into the lungs.

Notes: Values are expressed as the mean ± standard deviation; n=5–6. **P<0.01; *P<0.05.

Abbreviations: AgNP, silver nanoparticles; BALF, bronchoalveolar lavage fluid; FA, filtered air; OVA ovalbumin.