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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Chem Biol Drug Des. 2013 Oct;82(4):10.1111/cbdd.12167. doi: 10.1111/cbdd.12167

Table 2.

Preliminary structure activity relationship study of compound 1

graphic file with name nihms484190t1.jpg
Compound R1 R2 R3 R4 IC50 (µM)
1 (lead) OCH2COOH H H H 47.2 ± 5.9
1–1 H H H H >400
1–2 H Cl H H >400
1–3 H H F H 276 ± 29
1–4 H OH OCH3 H >400
1–5 H H NO2 H 80 ± 5
1–6 H H Cl H 89 ± 12
1–7 Cl H Cl H 111 ± 9
1–8 H OCH3 OH H 231 ± 60
1–9 H OCH2CH3 OH H >400
1–10 H OCH3 OH Br 136 ± 20