Table 2.
Compound | R1 | R2 | R3 | R4 | IC50 (µM) |
---|---|---|---|---|---|
1 (lead) | OCH2COOH | H | H | H | 47.2 ± 5.9 |
1–1 | H | H | H | H | >400 |
1–2 | H | Cl | H | H | >400 |
1–3 | H | H | F | H | 276 ± 29 |
1–4 | H | OH | OCH3 | H | >400 |
1–5 | H | H | NO2 | H | 80 ± 5 |
1–6 | H | H | Cl | H | 89 ± 12 |
1–7 | Cl | H | Cl | H | 111 ± 9 |
1–8 | H | OCH3 | OH | H | 231 ± 60 |
1–9 | H | OCH2CH3 | OH | H | >400 |
1–10 | H | OCH3 | OH | Br | 136 ± 20 |