Fig 6.

Sorafenib suppressed partial hepatectomy-induced liver regeneration via down-regulating NF-κB activation. The livers were harvested at 24, 72, and 120 hours after PHx and weighted. The ratios of liver weight over the whole body weight were shown. The values represents means±SD, with n=4 for each group. (A). Expression of PCNA in the livers was evaluated with immunohistochemical staining. Original magnification ×200 (B).Sorafenib or vehicle treated mice were imaged for luciferase expression at indicated time points following PHx (C). Quantitation of luciferase signal from the liver was shown (n=4).The results are representative of 2 experiments. (D).