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. 2013 Nov 1;3(11):865–884. doi: 10.7150/thno.5771

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 7 — Imaging of Vascular Remodeling. Vascular remodeling can be assessed with an Elastin-targeted Magnetic Resonance Agent (=ESMA). Panels A and B show ESMA-enhanced MR images of the aortic arch and supraaortic vessels in swine wit increased SNR and CNR compared to non-targeted Gd-DTPA (Panel C and D). A similar approach is able to detect vascular injury following coronary stent implantation. Magnetic Resonance Angiography (MRA, Panel E), delayed-enhancement MRI after injection of ESMA (Panel F) and fusion of E and F (Panel G). Quantification of Elastin by MRI yields good correlation with Histology (Panel H). Images courtesy of Marcus Makowski and René M. Botnar, Kings College London and Christian von Bary, Universität Regensburg.