Figure 11.

LM22A-4 prevents deficits in dendritic spines of BACHD striatal MSNs. A, Reconstructed drawings from Neurolucida tracings of one dendritic tree of Golgi-stained MSNs in striatum of WT (left) and BACHD mice (right) treated with vehicle (Veh; top) or LM22A-4 (LM-4; bottom). Scale bar, 10 μm. B, Spine density of MSNs was reduced in Veh-treated BACHD mice on dendritic branch orders 3–5 (*p ≤ 0.05 vs WT Veh, ANOVA and Newman–Keuls post hoc test, right graph) particularly on third and fourth orders (*p ≤ 0.05 vs WT Veh, Student's t test, left graph); this reduction was prevented by LM-4 (⁺p ≤ 0.04 vs BACHD Veh, Student's t test; n = 9–10/group). Results are expressed as mean ± SEM.