Table I.
Trade Names and Physical Characteristics of Selected Silicates Used in this Study
| Trade name | Aerosil® 200 Pharma | Neusilin® UFL2 | Neusilin® US2 | Sipernat® 22 | Sylysia® 350 FCP | Zeopharm ®600 |
|---|---|---|---|---|---|---|
| Supplier | Evonik Degussa, Parsippany, NJ, USA | Fuji Health Science, Burlington, NJ, USA | Fuji Health Science, Burlington, NJ, USA | Evonik Degussa, Piscataway, NJ, USA | Fuji Silysia Chemical USA, LTD., Greenville, NC, USA | J.M. Huber Corporation, Atlanta, GA, USA |
| Physical form/chemical composition | White powder. Silicon dioxide (100%)a | White powder. Magnesium aluminometasilicate: mixture of aluminum oxide (32.0%) + magnesium oxide (12.4%) + silicon dioxide (31.9%)a | White granules. Magnesium aluminometasilicate: mixture of aluminum oxide (31.0%) + magnesium oxide (12.3%) + silicon dioxide (31.9%)a | White powder. Silicon dioxide (98%)a | White powder, Silicon dioxide (99.5–100%)a | White powder. Calcium oxide (24%) + silicon dioxide (57%)a |
| Mean particle size (μm) | Nanosized branched chain aggregates of colloidal silicon sioxideb | 2–8e | 60–120g | 120c | 1.8h | 6j |
| Oil adsorbing capacity (ml/100 g) | 255c | 270–340f | 270–340f | 235c | 300a | 450a |
| Specific surface area (m2/g) | 200a | 300f | 300g | 190a | 300h | 300k |
| Bulk Density (g/cc) | <0.05d | 0.06–0.11f | 0.13–0.18f | – | 0.12–0.18i | 0.1k |
| pH (4% / 5% slurry) | 3.5–5.5a (4%) | 6.0–8.0f (4%) | 6.0–8.0f (4%) | 6.5a (5%) | 6.0–8.0a (5%) | 9.5–10.2a (5%) |
aFrom Certificate of Analysis or MSDS of respective product.
bEvonik Industries. AEROSIL® Colloidal Silicon Dioxide for Pharmaceuticals, Technical Information TI 1281.
cEvonik Industries. Converting liquids to dry flowable powders and retaining flavors on SIPERNAT® specialty silica and AEROSIL® fumed silica [Internet]. 2012. Available from: http://www.sipernat.com/sites/dc/Downloadcenter/Evonik/Product/SIPERNAT/TI%201367%20us.pdf
dFrom product brochure.
eFuji Chemical Industry Co., Ltd. Neusilin The Extraordinary Excipient for Oral Solid Dosage Forms. 2007 Oct; Available from: http://www.fujichemical.co.jp/english/newsletter/newsletter_pharma_0710.html
fFuji Chemical Industry Co., Ltd. General Properties of Neusilin. 2009 2010; Available from: http://www.neusilin.com/product/general_properties.php
gFuji Chemical Industry Co., Ltd. Neusilin The Extraordinary Excipient for Oral Solid Dosage Forms. 2007 Nov; Available from: http://www.fujichemical.co.jp/english/newsletter/newsletter_pharma_0711.html
h http://www.aquachem.co.kr/product/Sylysia.htm
iFuji Silysia Chemical LTD. Sylysia® FCP Product brochure; Available from: http://www.tcrindustries.com/FineChemical/Principals/BROCHURES/fujibrochures/FCP%20Brochure.pdf
jCompany product literature.
kM. Hall (personal communication, October 19, 2011)